Asheville, located in Western North Carolina, is reached via I-26 from the South (Greenville/Spartanburg) and I-40 from the East (Statesville) and West (Knoxville). Those traveling from the North will take 19/23 out of Johnson City.
Take the I-240 loop to get to downtown Asheville. (There are large signs for 240 for travellers on 40, 19/23, and 26.) Exit at Patton Avenue or Charlotte Street. Turn south to get to city center.
If you miss 240, take Exit 50 off I-40, and travel north on Route 25 (Biltmore Avenue).